Boettcher Foundation Helps Early-Career Scientists
By: Colorado BioScience Association Date: 08/29/2017
Funding Propels Investigators’ Research
The Boettcher Foundation launched its Webb-Waring Biomedical Research Awards with the goal of helping early-career investigators advance their research to a point where they would qualify for their first major federal grants.
As part of our ongoing Breakthrough Profiles series, Colorado BioScience Association is pleased to highlight the Boettcher Foundation’s Webb-Waring Biomedical Research Awards program. In 2017, recipients were awarded $235,000 in grant funding to sustain three years of biomedical research and honored with the title of Boettcher Investigator.
Since the first class was selected in 2010, Boettcher Investigators have gone on to receive major funding from a variety of federal sources, including the National Institutes of Health (NIH) and U.S. Department of Defense. Now, a new form of funding from the NIH is giving both the Boettcher Foundation and its investigators another reason to celebrate.
Maximizing Investigators’ Research Awards, or MIRA grants, are a new form of funding designed to allow researchers to take bigger risks and explore new ideas that may not have qualified for funding before.
The first round of MIRA grants were awarded in the fall of 2016 as part of a pilot program. Colorado researchers snagged seven of the awards, ranking the state fourth for the total number of MIRA grants received, just behind California, New York and Pennsylvania. Of the seven Colorado MIRA grants, five went to Boettcher Investigators.
“Our goal with the Webb-Waring Biomedical Research Awards is to keep Colorado’s top scientists in the state and allow them to develop their research to a point where it will bring in major grant funding,” said Katie Kramer, President and CEO of the Boettcher Foundation.
“The fact that Boettcher Investigators have been so successful in securing MIRA grants is an incredible validation of our selection process and our funding model,” Kramer added.
MIRA grants, which are awards by the National Institute of General Medical Sciences, differ from traditional NIH funding, which tends to fund more specific and well-developed research. An investigator is typically expected to have a very specific hypothesis, whereas MIRA is intended to fund more innovative projects that contribute to the general understanding of science rather than proving a specific outcome.
“People were making their applications extremely safe,” said Lucas Argueso, a 2013 Boettcher Investigator and an associate professor in the Department of Environmental and Radiological Health Sciences in the College of Veterinary Medicine and Biomedical Sciences at Colorado State University. “Scientists were becoming too conservative. It’s hard to predict which science is going to give you breakthroughs.”
Argueso was awarded MIRA funding for his research, which examines a form of genetic change known as copy number mutation. In addition to Argueso, CSU Boettcher Investigators Tai Montgomery, an assistant professor in the Department of Biology, and Tim Stasevich, an assistant professor in the Department of Biochemistry and Molecular Biology, also received MIRA funds.
At the University of Colorado, Boettcher Investigators Loren Hough and Aaron Johnson were also MIRA recipients. Hough is an assistant professor of physics and Johnson is an assistant professor in the Department of Integrative Biology.
Hough is researching how a protein tail on microtubules might control different features of a cell.
“This research is, in all regards, very different,” Hough said, adding that receiving a Webb-Waring Award from the Boettcher Foundation gave him the confidence to continue pursuing new directions in his research. “It’s a risk to take on something new, especially as a professor,” he noted.
Lee Niswander, a professor and section head for developmental biology at CU, who serves on the CU selection committee for the Boettcher Foundation’s Webb-Waring Awards, noted that the Webb-Waring Awards and MIRA are a natural combination.
“What’s so lovely about the Boettcher Foundation funding is they really do value original and creative thinking,” she said.
By helping propel the research of Colorado’s top early-career scientists, the Boettcher Foundation is helping the state of Colorado become a leader among scientific innovators and to support out-of-the-box thinking among Colorado’s researchers.