b"PharmaJet Tropis ID is used to vaccinate children in Somalia needles by combining single-use needle-freeyear, Cappello says. These companies areUMOJA BIOPHARMA: BUILDING FOR THE syringes with an injection system designedinterested in testing various vaccines andFUTURE FOR CELL AND GENE THERAPYfor at least 20,000 repetitions. The combinedmedications with the Tropis ID and its sister system is cost competitive with traditionalproduct, the Stratis IM/SC, which injects 0.5Chimeric antigen receptor T cells (CAR T cells) needle and syringes and provides multiplemilliliters into muscle cells, Cappello says.have proven to be powerful weapons in benefits, Cappello says.the fight against cancer, and Colorado has Cappello cites Colorados ability to attractbeen a leader in advancing this lifesaving The PharmaJet Tropis ID System has beentalent as a key factor in PharmaJets successimmunotherapy. But CAR T-cell therapy has used for millions of injections in multiplehere. Hes an example of that. The Goldentwo drawbacks. The first is that CAR T-cell immunization campaigns worldwide, includingnative had moved to California after earningtherapy is not yet approved for solid tumors. two commercially available COVID-19 vaccineshismechanicalengineeringdegreeatThe second is that the process of harvesting a in India, exclusively delivered through theColorado State University. A couple of yearscancer patients T cells, genetically engineering Tropis ID system. Because the skin hosts alater, he was looking for a mission-driventhem, and then waiting for the engineered lot of immune-related cells, injecting vaccinescompany with a medical device that couldcells to multiply in a bioreactor takes about into the dermal layer instead of the musclehave a global impact.40 days. Thats led to big bottlenecks, and below, triggers an outsized immune reaction.Right in my backyard, there was one thatmany patients are sick enough that they dont In Pakistan, with World Health Organizationchecked all the boxes, Cappello says. survive the wait.(WHO) approval, theyve been able to use one-fifth of the polio-vaccine dose that would be needed in a needle and syringe, So were vaccinating five times as many children withFROM CONCEPT TO COMMERCIALIZATION:the same amount of vaccine, Cappello says. RELY ON HALLORAN TO ACHIEVE SUCCESSWhats more, ditching needles boosts vaccine compliance by about 20%, Cappello says, inHalloran Consulting Group is a life science consulting firm providingaddition to avoiding needle-stick injuries andstrategic development, regulatory, quality, clinical, and organizationaldisease transmission from needle reuse.support to industry leaders in the pharmaceutical, biotech, andmedical device sectors. The pharmaceutical industry has taken note.Let's get to work. Visit us at hallorancg.comThe 20-employee PharmaJet is collaborating with more than 100 partners from around the world and adding 30 to 40 partners a Life science insight, life-changing impact2023-2024 BIOSCIENCE COLORADO 9"